GistMD's personalized patient engagement platform provides a flexible and patient centered framework for bridging communication gaps between patients and healthcare providers across the full spectrum of clinical and regulatory situations. Gist's Mission Gist’s proprietary technology will empower patients worldwide to access, read, understand, and utilize healthcare information whenever they need to make informed health decisions and follow treatment instructions. ABOUT gist The most important pieces of information about something Oxford English Dictionary Challenge Low levels of health literacy and patient engagement are associated with poor treatment outcomes, significantly extended hospital stays, higher readmission rates, and higher hospitalization costs. Solution Based on the understanding that personalized patient education is a fundamental precondition for effective patient engagement, we’ve developed a platform enabling highly scalable production of personalized content, profoundly improving patient engagement and literacy levels. PRODUCT Our Platform Gist’s proprietary technology seamlessly combines animated video segments into an interactive video on the planned procedure, needed preparation, and recovery process. TEach video is tailored to the patient’s language, age, gender, medical condition, procedure, and local clinical guidelines. 55% reduction in preoperative meetings 50% drop in outpatient no-shows 60% improvement in colonoscopy bowel preparation adherence Link 22% improvement in screening test scheduling activation Link 80% decrease in Workload for Medical Staff Adaptable to Every Clinical Setting Gist’s personalized patient engagement platform provides a flexible framework for bridging communication gaps between patients and healthcare providers across the full spectrum of clinical and regulatory situations. The platform’s modular architecture and SaaS-based use model make it highly adaptable to varied parameters on the national, healthcare facility, patient routine, and individual patient levels. See Example Deployment Proud To Collaborate With Meet Our Team Gist’s executive team has extensive experience leading private and public health-tech companies with a strong focus on personalized medicine. The team is supported by a multidisciplinary group of top experts in medicine, artificial intelligence and machine learning, health policy, animation and visual communication, anthropology, and psychology. Dan Rolls Founder and CEO A serial entrepreneur specializing in digital healthcare and patient engagement Prof. Ori Rogowski Co-founder and CMO Director, Internal Medicine C, Tel Aviv Medical Center Prof. Amir Lerman, MD Board Member & Chief Medical Advisor, Cardiology Prof. Lerman is Head of Cardiology Research at the Mayo Clinic at the prestigious Mayo Clinic. He also leads the Department of Innovation Research and the Application of Artificial Intelligence Prof. Idit Matot Chief Medical Advisor, Anesthesiology Prof. Matot, President of the European Society of Anesthesiology & Intensive Care, she brings extensive expertise and leadership to the forefront of the anesthesiology and intensive care across Europe click to see associated product Allison Gordon, MBA Senior Advisor, Strategy and International Growth Harvard and MIT-trained strategist with a background in finance, global ventures, and social impact. Leads international growth and partnerships to scale digital health engagement. Dr. Ilan Cohn Co-founder & Chairman Dr. Cohn leverages his extensive experience in founding and developing healthcare companies and building intellectual property assets to guide GistMD's innovation and strategic growth Zvi Zahavi, MD Board Member Dr. Zahavi brings extensive experience in digital health entrepreneurship, improving communication between caregivers, healthcare organizations, and market expansion BenAmi Goldenberg Co-founder and CTO Tech entrepreneur and AI innovator with 20+ years of experience in software engineering, product strategy, and startup leadership. Elinor Karni UI/UX and Product Design Manager With over 20 years of expertise in developing digital identities, products, and creating unique digital experiences, Elinor leads product design at GistMD Daniella Benaim Community Manager Daniella leads GistMD's social media presence and communication strategy, fostering community engagement and supporting our mission Prof. Zvi Grunwald Chair, Department of Anesthesiology Jefferson Health Clinician The James D. Wentzler Professor and emeritus chair of anesthesiology at Sidney Kimmel Medical College. click to see associated product Prof. Shmuel Banai Chief Medical Advisor, Cardiology Director, Cardiology Division, Tel Aviv Medical Center Revital Shahar Research Nurse Revital leverages her expertise in nursing research to enhance patient care and contribute to GistMD's innovative solutions Tamar Ish Cassit Medical & Assistive Device Design Expert Business Consultant and Expert in Medical & Assistive Device Design Prof. Yariv Yogev Chief Medical Advisor, Obstetrics and Gynecology Director, Lis Maternity and Women's Hospital, Tel Aviv Medical Center click to see associated product Prof. Anat Loewenstein Chief Medical Advisor, Ophthalmology Director, Ophthalmology Department, Tel Aviv Medical Center; President, Israel Ophthalmology Society; World-Renowned Ophthalmologist click to see associated product Isaac Brzezinski Sinai, MD Medical Advisor, Anesthesiology Anesthesia Department Resident, Tel Aviv Medical Center Prof. Ofer Havakuk Medical Advisor, Cardiology Prof.. Havakuk leads development of GistMD’s heart failure program Prof. Fahed Hakim Chief Medical Advisor, Pediatrics Director, Nazareth Hospital EMMS and chief medical advisor Her young life was brutally extinguished on October 7 by Hamas terrorists Osher Barzilay A fallen soldier Represented the best of us Cameron Birnbaum Healthcare Strategy & Operations Analyst Builds data-driven models that map the impact of personalized digital interventions on health outcomes and financial performance. Focused on translating patient engagement into measurable value for patients, providers, and health systems. Liat Deutsch, MD Medical Advisor, Gastroenterology Head of the clinical nutrition service, Department of Gastroenterology & Liver diseases, Tel Aviv Medical Center Nehama Karpol Burak Psychologist Nehama enhances patient engagement through her expertise in human behavior, emotions, providing personalized and empathetic care Prof. Zaza Iakobishvili Chief Medical Advisor Director, Community Cardiology, Tel-Aviv District, Clalit Health Services Daniel Nav e, PhD Anthropologist Daniel enhances engagement strategies by incorporating cultural insights and an appreciation for patient consciousness Demetria Bolden, PHD Heath Equity Dr. Bolden leverages her expertise in health equity research to enhance patient empowerment by addressing disparities in healthcare access and outcomes Bat Zion Shachar, MD Medical Advisor, Gynecology Attending, Gynecology and Obstetrics, Maccabi Healthcare Services Director of Clalit Child Health Center Orit Neudorfer, MD Chief Research Officer Focused on building and scaling digital SaaS products, he brings a strong mix of product thinking, data-driven growth, and cross-functional collaboration. Wisam Yaghmour Strategy and Patient Experience Prof. Maayan Konigstein Medical Advisor, Catheterization Head of the clinical nutrition service, Department of Gastroenterology & Liver diseases, Tel Aviv Medical Center Aviva Shemer Strategy and Patient Experience With over 20 years of experience managing the service and marketing departments at TLV Medical Center, Aviva has been accompanying GistMD since its inception Sari Masri Software Developer Building and scaling healthcare software, he focuses on product strategy, user adoption, and system integration. Ido E. Kunst CISO Manager Ido, with 20+ years of experience Chief Information Security Officer (CISO) & Data Protection/Privacy Officer (DPO) B.Sc. in Computer Science | FullStack | NodeJS | React | Java Spring Boot | Python | C++. Ramadan Jaafari Programmer Ronen Zhurat Chief Producer Experienced Owner with a demonstrated history of working in the animation industry. Animation Director, 2D & Flash Animator, Storyboard artist, Character designer & illustrator Avi Blyer Chief Creator Officer We’re excited to share the first publication about our collaboration with Mayo Clinic—featured in The Jerusalem Post! This is a powerful moment of validation for our team at GistMD, and a great opportunity to highlight how personalized digital education can transform patient care. Read at The Jerusalem Post

Discharge Post-discharge is one of the most challenging phases in a patient's healthcare journey. The Gistmd’s Discharge Education Module engages patients to continue their treatment at home and effectively manage their recovery. The module helps patients to better understand the post-discharge demands, step by step. Using the personalized video and a user-friendly interface, the program guides patients in grasping the importance of maintaining follow-ups with their family doctor, undergoing follow-up tests, and staying consistent with their new prescribed medications. How it works Effortless Gui dance Follow-ups Our intelligent engagement system simplifies the task of monitoring the patient’s follow-up care The easy and simple method to create a personalized post-discharge intervention The method must be simple, yet comprehensive, considering individual patient factors like clinical condition, demographics, and personal preferences Tailor-Made Education Module: A Personalized Pathway to Empowerment In the complex world of healthcare, one size does not fit all. Every patient's journey is influenced not only by unique demographic and clinical characteristics but also by expected outcomes Let’s gist! The most important information for the patient is in the palm of his hand Recovery doesn't end at discharge, and neither does our commitment. Gistmd’s Discharge Education Module is designed with empathy, innovation, and a patient-centered approach

Preanesthesia Patient Education Kit Benefits + Effective pre-procedure guidance, accurate calibration of expectations, and increased patient satisfaction + Improved patient engagement and safety through use of personalized tools + Reduction in preanesthesia evaluations The Adult Preanesthesia Patient Education Kit was designed and developed by a multidisciplinary team of senior physicians in the fields of anesthesiology, intensive care and pain. Patient engagement is personalized based on information entered by the surgery coordinator and by the patient, who fill out a preoperative questionnaire. Patients whose background condition does not justify a pre-anesthesia evaluation and have viewed a personalized video, are exempted from a pre-anesthesia evaluation. + + + How it works 1 After a decision on a procedure is made, the surgery coordinator opens a new event on the platform 2 Patient receives text message from hospital with link to video and preoperative questionnaire 3 Patient fill out questionnaire 4 Patient views personalized video 5 Patient affirms receipt and understanding of preoperative instructions The patient is presented with questions equivalent to points regarding medical background, lifestyle, functional abilities and more Patients' responses to preoperative questionnaire enable hospital anesthesiology team to pre-screen for necessity of a preanesthesia evaluation Scoring System The patient must come to a preliminary meeting with an anesthesiologist. Exemption from a preliminary appointment and will meet the anesthesiologist only on the day of surgery 2 points or more less than 2 points Request Demo

Labor Induction Navigating the journey of childbirth can be both exciting and challenging. To support and empower expecting mothers through this unique phase, GistMD presents its ‘Personalized Labor Induction Education Program’. Through this innovative platform, we aim to demystify the labor induction process and to prepare women for what to expect. This leverages the power of digital health and offers a personalized, engaging, and empowering learning experience. Benefits Improves patient preparation Increases patient satisfaction How It Works The clinic sends the patient a link to her mobile phone Patient fills out a personalization questionnaire 4 Based on the the answers to the questionnaire, the system automatically creates a personalized animated video and screens it to the patient Patients are encouraged to download, read and print a personalized informed consent form 1 2 3 ״Providing a pregnant woman with organized information through a video, illustrating what she can expect during the birthing process, leads to fewer surprises and greatly facilitates the entire experience. This approach not only assists us the midwifes, but also reduces the need for extensive explanations from doctors.״ ״If I was a pregnant woman with limited knowledge, being provided with a video explaining what an epidural entails would have greatly boosted my sense of preparedness, confidence, and understanding. It exemplifies the potency of knowledge, which effectively reduces feelings of fear, anxiety, and uncertainty.”

Intravitreal Injections Using a personalized animated video, the Intravitreal Injections Education Module effectively engages patients and encourages them to begin and complete their treatment course. In addition to bridging anxiety-inducing information gaps and providing personalized preparatory instructions, the Module taps into the power of empathy to improve engagement using a personalized simulation of the vision-affecting symptoms experienced by the patient. Click on the images to to see how the video is personalized to the patient's condition Demonstrating empathy by simulating the patient's symptoms Retinal Vein Occlusion RVO AMD Age Related Macular Degeneration DME Diabetes Related Macular Edema System benefits Improves patient preparation Reduces medical and administrative staff workloads Bridges crucial information gaps Patient journey Patient Clinic Unengaged patients receive reminders 96 and 48 hours ahead of procedure The platform monitors patient engagement and sends reminders to unengaged patients 96 and 48 hours ahead of procedure. Patients unresponsive to their last reminder are flagged for direct intervention by clinic staff (see below). Clinic staff open a new patient case and update the patient’s personal information (age, gender, and language preference), the indication for treatment (RVO, AMD, or DME), the date and time of the procedure, and the patient’s mobile phone number. Optionally, the clinic’s patient management system can be connected directly to the platform. New patient case opened by clinic 1/4 Patients and/or caregivers receive an SMS with link to personalized animated video Patients and/or caregivers receive an SMS to their mobile phone with a link to a personalized animated video and personalized preparatory instructions. video 1/3 An easy-to-use administration module monitors patient engagement. Unengaged patients are flagged for direct intervention by staff. The module provides reports in a number of formats. Administration module monitors patient engagement 1/1 Case Manager 2.O Digitized informed consent form Patients are encouraged to read the personalized informed consent form they will sign in the presence of a physician at the clinic. After watching the video, the patient can view, download and print personalized preparatory instructions. Personalized preparatory instructions "I've been treated with intravitreal injections for two years now. I watched the video and it’s simply amazing! I identified with the character and her symptoms, and I really liked that the video explained how the substance works in the eye. After watching it, I suddenly understood the treatment and what happens inside my eye." Patient, 58 “I truly appreciated the clear and lighthearted manner in which the instructions were presented. Despite having undergone multiple injections in the past year, the video still provided valuable assistance. It's wonderful to receive such a pleasant video on my phone, addressing me directly." Patient, 76

Change a stoma bag Stoma - Care Principles Explore GistMD's Stoma Care Principles Guidance System, encompasses empowerment, support, and patient engagement. Our personalized education equips individuals for effective stoma management, enabling them to better adapt to their new medical condition. Tailored materials empower patients to confidently manage their stoma care, promoting self-sufficiency in managing their condition. Patient education regarding stoma’s care principles can pose challenges to the medical staff but GistMD's platform is here to assist them! Using comprehensive and accessible information, our platform empowers patients to proactively manage their care. This not only reduces the patient’s need for guidance but also saves valuable time for medical staff. What is Stoma? Patient journey Patient Clinic Receiving a text message and choosing Personal Avatar GistMD helps patients adapt smoothly to life with stoma, at home as part of their daily routine. We offer important insights, helping patients recognize the red flags and better understand what is considered an emergency, and demands consulting with specialized stoma nurses. Stoma Care in daily routine Patients receive a text with a link for instant access to our web platform - no downloads needed. The patients can customize their experience by choosing an avatar that reflects their identity better: gender, age, and ethnicity. This personalized character will appear in the educational videos, making learning both informative and relatable. Monitoring patient engagement Our platform actively monitors compliance data and engagement by tracking patient actions such as link access, questionnaire completion, and video views. This valuable data equips clinicians to offer targeted support to those facing challenges with the guidance system. Moreover, the platform can send reminders to unresponsive patients, ensuring they remain dedicated to their stoma care treatment. Personalized Stoma Care Principles Guidance The nurse creates cases for new patients, considering the patient’s individual stoma type and needs. Personalized educational videos are tailored accordingly. Integrating our platform with the division's management system adds convenience for healthcare staff. Creating a new case Artboard 1 stoma-gallry-2-heb Artboard 1 1/2 GistMD offers personalized stoma care guidance, empowering patients well - being by providing them a sense of control and self-sufficiency. We provide them with practical instructions for managing stoma care, including information about their specific equipment. From dietary guidelines to intimate relationships, we address physical changes and provide guidance for a more empowered living. Our aim is to ensure that patients are well-informed in their journey adapting to lifestyle changes.

The GistMD Solution for Pre-Anesthesia Education for Children Deployed at Tel Aviv Sourasky Medical Center in 2020 Benefits + Effective pre-procedure guidance, accurate calibration of expectations, and increased patient satisfaction + Improved patient engagement and safety through use of personalized tools + 50% reduction in pre-anesthesia evaluations How the product was used to reduce 50% of pre-anesthesia evaluations Product designed and developed by a multidisciplinary team of senior physicians in the fields of anesthesiology, intensive care, and pain. Patient's animation is personalized based on information entered by the surgery coordinator and by the patient's parents, who fill out a preoperative questionnaire. Patients whose background condition does not justify a pre-anesthesia evaluation and have viewed a personalized video, are exempted from a traditional pre-anesthesia evaluation. How it works After a decision on a procedure is made, the surgery coordinator opens a new event on the platform 1 2 Parents of patients receive a text message from hospital with link to video and preoperative questionnaire 3 Parents fill out questionnaire 4 Parents and patient view personalized video 5 Parents affirm receipt and understanding of preoperative instructions Parents responses to preoperative questionnaire enable hospital anesthesiology team to pre-screen for necessity of preanesthesia evaluation 1 2 10 1 1/10 If parents entered negative responses to all questions, and viewed the video, no further evaluation is required, and the patient arrives at the hospital on the day of the surgery, meeting the anesthesiologist at the operating room. If parents did not respond to the questionnaire, or entered one or more positive responses, a separate pre-anesthesia evaluation at the hospital is scheduled for the patient. No Yes "The instructions were clear, and I understood the steps. My daughter hasn't had surgery before. Knowing that she might act differently after the surgery was reassuring because it's normal after anesthesia. If I didn't know this, I would have been very anxious" Mother of the pateint "The video was both pleasant and informative, clearly explaining the process and soothing my nerves. As someone who prefers to have a comprehensive understanding, it was reassuring to know everything in advance. It was user-friendly and the reassuring tone made it less intimidating." Patient, 8 Request Demo

Fall Prevention Program With the impact of personalized animated videos, the ‘GistMD Hospital Fall Prevention Program’ engages patients and healthcare professionals in effective ways to prevent falls. By bridging information gaps and embracing cultural sensitivity, the program ensures health equity and health literacy. Through an interactive and multilingual platform, the program delivers personalized risk assessments, and empathy-driven education for patients and caregivers, to improve safety and patient engagement. How it works GistMD's ‘Hospital Fall Prevention Program’ begins with a comprehensive assessment to pinpoint an individual's specific fall risk factors. The program delivers culturally sensitive, personalized animated video education, in multiple languages tailored to these identified risks. The program provides a robust monitoring system, capturing real-time data on patient education and activation at both departmental and hospital-wide levels for efficient program evaluation and improvement.

Terms of Use Last Revised: April 24, 2022 Gist Med Ltd. and its affiliates (collectively, “ GistMD ”, “ Company ”, “ we ”, “ our ”, or ” us ”) welcome you (the “ User(s) ” or “ you ”) to our website at https://www.gistmd.com/ (the “ Site ”). Each of the Site’s Users may use the Site in accordance with the terms and conditions hereunder. 1. Acceptance of the Terms By entering, connecting to, accessing, or using the Site, you acknowledge that you have read and understood the following terms of use, including the terms of our Privacy Policy available at Privacy Policy (collectively, the “ Terms ”). You agree to be bound by them and comply with all applicable laws and regulations regarding your Site use. You acknowledge that these Terms constitute a binding and enforceable legal contract between GistMD and you. IF YOU DO NOT AGREE TO THESE TERMS, PLEASE DO NOT ENTER, CONNECT, ACCESS, OR USE THE SITE IN ANY MANNER. 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Epidural Anesthesia The Module empowers pregnant women with the information required to make informed decisions regarding epidural anesthesia use during labor. This is achieved using a personalized animated video that provides the pregnant woman with clear and concise information -- on the procedure, on its risks, on common misinformation, and on alternatives -- weeks ahead of her due date. Benefits Improves patient preparation Increases patient satisfaction How It Works 1 The clinic sends the patient a link to her mobile phone 2 Patient fills out a personalization questionnaire 4 3 Based on the the answers to the questionnaire, the system automatically creates a personalized animated video and screens it to the patient Patients are encouraged to download, read and print a personalized informed consent form 2 ״Providing a pregnant woman with organized information through a video, illustrating what she can expect during the birthing process, leads to fewer surprises and greatly facilitates the entire experience. This approach not only assists us the midwifes, but also reduces the need for extensive explanations from doctors.״ ״If I was a pregnant woman with limited knowledge, being provided with a video explaining what an epidural entails would have greatly boosted my sense of preparedness, confidence, and understanding. It exemplifies the potency of knowledge, which effectively reduces feelings of fear, anxiety, and uncertainty.”

Insulin Video Diabetes Our Personalized Education Kit for Diabetic Patients is an informative and engaging resource, that helps patients to manage and cope with their diabetes, and by that empowers them. The personalized user-friendly interface and videos help the patient to better understand the different phases of their treatment and encourages them to take an active role in their care by making informed decisions and confidently managing their diabetes. Patient engagement is a key to success – increasing engagement leads to better outcomes. Blood Sugar Video Patient journey Patient Clinic Receiving a text message Patients and/or caregivers will receive a text message containing a link to the Gistmd platform on their mobile phones. The link provides quick access to the interface, eliminating the need for any downloads. Once the patient has accessed the platform, they can choose their preferred avatar based on their gender, age, and ethnic origin. This personalized avatar will then feature in their animated educational video, tailored to their specific background and preferences. Effortless Personalization: Our Innovative Recombination Algorithm The full video is created instantly and divided into three parts, representing different stages of injection or use of the glucometer. Patients can easily switch between the parts, allowing for comfortable viewing of the content they are interested in, and to receive all the necessary information for measuring blood sugar and injecting insulin correctly, efficiently, and safely. Tracking Patient Compliance To ensure that patients remain engaged with their diabetes management, the platform monitors their compliance data and engagement by tracking whether they have opened the link, answered the questionnaire, or watched the educational video. By having access to this data, clinicians can provide more effectively for those who struggle. Additionally, the platform sends notifications to patients who are unresponsive to text message reminders. This helps to ensure that patients stay on top of their diabetes management and receive help to effectively manage their condition. Optimizing Diabetes Management: Visual Guidance for Injection Areas When a new patient visits the clinic, the clinic staff will create a new case for them and update their personal information. Depending on the patient's needs, the type of pen prescribed and information, the educational videos will also be defined and sent accordingly - this may include a sugar test video, an insulin injection video, or both. Furthermore, the clinic's managemen t system can be integrated with the Gistmd platform for even greater convenience for the clinicians and staff. Creating a new case